Bone marrow metastasis from testicular seminoma in a patient with concomitant follicular non-Hodgkin lymphoma: A case report

Introduction. Seminomas are the most common testicular tumors. Initial therapy includes orchiectomy with resection of local lymph nodes, followed by adjuvant radiotherapy. Testicular tumors usually metastasize to retroperitoneal and mediastinal lungs, liver, spleen, gastrointestinal tract, adrenal glands. Bone metastases from very rare, while seminoma metastasis bone marrow is a curiosity, without any references in scientific literature. Case Report. A 66-year-old patient, previously treated for follicular non-Hodgkin lymphoma, was admitted due complaints malaise, abdominal back pain, hepatosplenomegaly. After examination radiologically verified enlarged patient referred hematologist. Based on patient?s medical history, relapse lymphoma suspected, biopsy performed. The hematoxylin-eosin staining sample showed diffuse large cell infiltrates bright cytoplasm, polygonal nuclei prominent nucleoli. By immunohistochemical staining, cells positivity cluster differentiation 10, 117, octamer binding transcription factor 3/4, placental alkaline phosphatase, cytokeratin 8/18, after which diagnosis made. Shortly histopathological made, died. Conclusion. tumor favorable prognosis. Due suppression hematopoiesis, generally lead worst outcome our highlights importance timely therapy, would increase chances survival.